Naftali Stern M.D, Professor of Medicine (emeritus) Sackler Faculty of Medicine Tel Aviv University Director, Institute of Endocrinology, Metabolism and Hypertension Tel Aviv-Sourasky Medical Center 6 Weizman street, Tel Aviv, Israel 64239 Medical license number: 13446 CLINICAL EXPERIENCE & PROFESSIONAL EDUCATION 10/69 - 7/75 Sackler School of Medicine, Tel-Aviv University: Received M.D., summa cum laude absoluto 09/75-09/76 Rotating Internship, Sheba Medical Center, Tel-Hashomer 11/76-06/81 Resident in Internal Medicine, Sheba Medical Center, Tel-Hashomer 07/81-06/83 Fellow in Endocrinology, UCLA – SFVP 09/1983 American Board of Internal Medicine Israeli Board of Internal Medicine 11/1985 American Board of Endocrinology and Metabolism Israeli Board of Endocrinology and Metabolism 1983-1988 Staff, Endocrinology Division, UCLA – SFVP 1983-1984 Chief, Diabetes Service, UCLA - SFVP 1984-1988 Chief, Endocrine-Hypertension, UCLA - SFVP 1988-2019 Chief, Institute of Endocrinology, Metabolism and Hypertension, Tel-Aviv – Sourasky Medical Center, Tel-Aviv 2019-present Director, The Sagol Epigenetics Center, Tel Aviv-Sourasky Med Ctr, Tel Aviv 06/2007 Good Clinical Practice Fundamentals (GCP) for Clinical Research Investigators ACADEMIC AND PROFESSIONAL EXPERIENCE 1983-1986 Assistant Professor of Medicine, UCLA School of Medicine, Los Angeles, USA 1986-1989 Associate Professor of Medicine, UCLA School of Medicine, Los Angeles, USA 1989-1991 Adjunct Associate Professor of Medicine, UCLA School of Medicine, Los Angeles, U.S.A. 1989 - Associate Professor of Medicine, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel 1999 - Professor of Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel NATIONAL AND INTERNATIONAL APPOINTMENTS 1988 – 1991 Chairman, Israeli Boards of Endocrinology and Metabolism 2000 - Chairman, Israeli Society of Hypertension committee for the approval of specialists in clinical hypertension (by the European Society of Hypertension) 2001 - Member, Review Board of the Israeli National Academy of Science 2001 - 2003 President, Israeli Society of Hypertension 2001- Israeli Delegate, World Hypertension League 2002- Ministry of Health Committee on the use of salt in the general Population 2003 - present Chairman, Research Committee, Israeli Society of Hypertension 2004 – present Member, Committee for Appointments and Promotions, Sackler Faculty of Health Sciences, Tel Aviv University 2003- Chairman, The Israeli Forum on Growth Hormone Therapy in Adult Growth Hormone Deficiency (by the Israeli Society of Endocrinology) 2004- Member, National Committee for Policy on Salt Consumption and Guidelines for Consumers and Food Industry 2008- 2016 Member, Scientific Council, International Society of Hypertension EDITORIAL ACTIVITIES Senior editor J CardioMetab. Syndr 2006- 2017 ֹ Member of Editorial Boards 1994-1997 Endocrinology 1988 - present International Journal of Clinical Pharmacology Research 2003- 2012 Israeli Bilingual journal of Hypertension 2012 - 2016 Diabetes 2012 - 2016 American Journal of Physiology, Endocrinology and Metabolism Publications, since 2013 (out of 267) 1. Shefer G, Marcus Y, Stern N Is obesity a brain disease?.Neurosci Biobehav Rev. 2013 ;37(10 Pt 2):2489-503. 2. Greenman Y, Kuperman Y, Drori Y, Asa SL, Navon I, Forkosh O, Gil S, Stern N, Chen A: Postnatal ablation of POMC neurons induces an obese phenotype characterized by decreased food intake and enhanced anxiety-like behavior..Mol Endocrinol. 2013 Jul;27(7):1091-102 3. Marcus Y, Shefer G, Sasson K, Kohen F, Limor R, Pappo O, Nevo N, Biton I, Bach M, Berkutzki T, Fridkin M, Benayahu D, Shechter Y, Stern N: Angiotensin 1-7 as means to prevent the metabolic syndrome: lessons from the fructose-fed rat model..Diabetes. 2013 ;62:1121-30 4. Somjen D, Grafi-Cohen M, Posner GH, Sharon O, Kraiem Z, Stern N:Vitamin D less-calcemic analog modulates the expression of estrogen receptors, vitamin D receptor and 1α-hydroxylase 25- hydroxy vitamin D in human thyroid cancer cell lines.J Steroid Biochem Mol Biol. 136:80-2, 2013 5. Rosenberg N, Bloch M, Ben Avi I, Rouach V, Schreiber S, Stern N, Greenman Y: Cortisol response and desire to binge following psychological stress: Comparison between obese subjects with and without binge eating disorder. Psychiatry Res. 208:156-61, 2013. 6. Somjen D, Katzburg S, Gigi R, Dolkart O, Sharon O, Salai M, Stern N.:Rivaroxaban, a direct inhibitor of the coagulation factor Xa interferes with hormonal- induced physiological modulations in human female osteoblastic cell line SaSO(2). J Steroid Biochem Mol Biol. 135:67-70, 2013. 7. Somjen D, Katzburg S, Sharon O, Knoll E, Stern N:Estrogens and Hyperglycemic Modulation of mRNAs Expressions Involved in Bone Metabolism:An Overshadowed Association? Connect Tissue Res. . 2013; 54:176-802013 8. Weisinger G, Grafi-Cohen M, Hirsh M, Knoll E, Sharon O, Many A, Limor R, Stern N: 12S- Lipoxygenase is Necessary for Human Vascular Smooth Muscle Cell Survival.Exp. Cell Res, 10;319:1586-93, 2013. 9. Klein A, Stern N, Osher E, Kliper E, Kesler A: Hyperandrogenism is Associated with Earlier Age of Onset of Idiopathic Intracranial Hypertension in Women. Current Eye Research, 38:972-6., 2013. 10. Greenman Y, Kuperman Y, Drori Y, Asa S, Forkosh O, Gil S, Schneidman E, Stern N, Chen A: Postnatal ablation of POMC neurons induces an obese phenotype and enhanced anxiety-like behavior Molec Endocrinol, 27:1091-102, 2013 11. Vaisvaser S, Lin T, Admon R, Podlipsky Klovatch I, Greenman Y, Stern N, Fruchter E, Wald I, Pine D, Tarrasch R, Bar-Haim Y, Hendler T: Neural traces of stress: cortisol related sustained enhancement of amygdala-hippocampal functional connectivity . Frontiers in Human Neuroscience, in press, 2013, Epub online 5/7/2013 12. Schwartz R, Kliper E, Stern N, Dotan G, Berliner S, Kesler A : The obesity pattern of idiopathic intracranial hypertension in men. Graefe's Archive for Clinical and Experimental Ophthalmology Epub ahead of print, August 18, 2013 13. A single-step approach to the diagnosis of primary hyperaldosteronism: filling a true void or burdening the bottleneck of adrenal vein sampling?Osher E, Marcus Y, Stern J Clin Hypertens (Greenwich). 2014 Jul;16(7):477-8 14. Safadi R, Konikoff FM, Mahamid M, Zelber-Sagi S, Halpern M, Gilat T, Oren R; FLORA Group. The Fatty Acid-Bile Acid Conjugate Aramchol Reduces Liver Fat Content in Patients With Nonalcoholic Fatty Liver Disease. Clin Gastroenterol Hepatol. 2014 ;12:2085-91. 15. Yaron M, Renner U, Gilad S, Stalla GK, Stern N, Greenman Y: KISS1 receptor is preferentially expressed in clinically non-functioning pituitary tumors. Pituitary. 2015 ;18:306-11 16. Scirica BM, Bhatt DL, Braunwald E, Steg PG, Davidson J, Hirshberg B, Ohman P, Frederich R, Wiviott SD, Hoffman EB, Cavender MA, Udell JA, Desai NR, Mosenzon O, McGuire DK, Ray KK, Leiter LA, Raz I; SAVOR-TIMI 53 Steering Committee and Investigators.: Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus. N Engl J Med. ;369:1317-26, 2013 17. Shaklai S, Shefer G, Stern N: A glucose-dependent FOXO1 switch in healing wounds: shred of hope for diabetic ulcers? Diabetes 64:6-8, 2015 18. D. Somjen, E. Knoll, O. Sharon, A. Many, N. Stern: Calciotrophic hormones and hyperglycemia modulate vitamin D receptor and 25 hydroxyy vitamin D 1-α hydroxylase mRNA expression in human vascular smooth muscle cells. J Steroid Biochem Mol Biol, 2015 ;148:210-3. 19. Yacobi-Bach M, Serebro M, Greenman Y, Tordjman K, Stern N. Thiazides Are Not Inducers of PTH Secretion: A Comment on Normocalcemic Hyperparathyroidism. Letter to the Editor. J Clin Endocrinol Metab. 2015; 100:L27-L28. 20. Osher E, Fattal-Valevski A, Sagie L, Urshanski N, Sagiv N, Peleg L, Lerman-Sagie T, Zimran A, Elstein D, Navon R, Valevski A, Stern N. Effect of cyclic, low dose pyrimethamine treatment in patients with Late Onset Tay Sachs: an open label, extended pilot study. Orphanet J Rare Dis. 2015 17;10:45. doi: 10.1186/s13023-015-0260-7 21. Pfeffer MA, Claggett B, Diaz R, Dickstein K, Gerstein HC, Køber LV, Lawson FC, Ping L, Wei X, Lewis EF, Maggioni AP, McMurray JJ, Probstfield JL, Riddle MC, Solomon SD, Tardif JC; ELIXA Investigators. Lixisenatide in Patients with Type 2 Diabetes and Acute Coronary Syndrome. N Engl J Med. 2015;373:2247-57 22. Pi-Sunyer X, Astrup A, Fujioka K, Greenway F, Halpern A, Krempf M, Lau DC, le Roux CW, Violante Ortiz R, Jensen CB, Wilding JP; SCALE Obesity and Prediabetes NN8022-1839 Study Group. A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management. N Engl J Med. 2015 ;373:11-22. 23. Green JB, Bethel MA, Armstrong PW, Buse JB, Engel SS, Garg J, Josse R, Kaufman KD, Koglin J, Korn S, Lachin JM, McGuire DK, Pencina MJ, Standl E, Stein PP, Suryawanshi S, Van de Werf F, Peterson ED, Holman RR; TECOS Study Group. Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 Diabetes. N Engl J Med. 2015;373:232-42. 24. Bentley-Lewis R, Aguilar D, Riddle MC, Claggett B, Diaz R, Dickstein K, Gerstein HC, Johnston P, Køber LV, Lawson F, Lewis EF, Maggioni AP, McMurray JJ, Ping L, Probstfield JL, Solomon SD, Tardif JC, Wu Y, Pfeffer MA; ELIXA Investigators. Rationale, design, and baseline characteristics in Evaluation of LIXisenatide in Acute Coronary Syndrome, a long-term cardiovascular end point trial of lixisenatide versus placebo. Am Heart J. 2015;169:631-638.e7. 25. Greenman Y, Stern N: Optimal Management of Non-functioning Pituitary Adenomas. Endocrine, 2015, 50:51-5. 26. Marcus Y, Segev E, Shefer G, Sack J, Tal B. Yaron M, Carmeli E, Shefer L, Margaliot M, Limor R, Gilad S, Sofer Y, Stern N: Multidisciplinary treatment of the metabolic syndrome lowers blood pressure variability independent of blood pressure control. J Clin Hypertens 2016; 18:19-24 27. Marcus Y, Stern N: Blood pressure seasonality in diabetic subjects: a call for attention. J Clin Hypertens, in press, 2016;18:267-9. 28. Maman E, Somjen D, Maman E, Somjen D, Maman E, Katzburg S, Sharfman Z, Stern N & Dolkart O: The response of cell derived from the Suprra-spinatus tendon to estrofens and calcitrophic hormones stimulation: In vitro study. Connective Tissue Research 2016; 57:124-30 29. Osher E, Scapa E, Klausner J, Greenman Y, Geva R, Blachar A, Stern N, Santo E: Panceatic incidentaloma: differebtiation of non-functioning pancreatic neuroendocrine tumor (PNET) from intra-pancreatic accessory spleen (IPAS). Endocrine Practice, February 26, 2016, [Epub ahead of print] 30. Yaron M, Izkhakov E, Sack J, Azzam I, Osher E, Tordjman K, Stern N, Greenman Y.: Arterial properties in acromegaly: relation to disease activity and associated cardiovascular risk factors. Pituitary. 2016 Feb 12. [Epub ahead of print] 31. Buch A, Carmeli E, Keinan-Boker T, Marcus Y, Shefer G, Kis O, Berner Y, Stern N: Muscle function and fat content in relation to sarcopenia, obesity and frailty of old age — An overview. Exp. Gerontol 2016; 76:25-32. 32. Izkhakov E, Somjen D, Sharon O, Knoll E, Aizic A, Fliss DM, Limor R, Stern N: Vitamin D receptor expression is linked to potential markers of human thyroid papillary carcinoma. J Steroid Biochem Mol Biol. 2016; 159:26-30. 33. Somjen D, Kohen F, Limor R, SharonO, Knoll E, Many A and Stern N: Estradiol-17beta increases 12- and 15-lipoxygenase (type2) expression and activity and reactive oxygen species in human umbilical vascular smooth muscle cells. J Steroid Biochem Mol Biol. 2016 March 23. [Epub ahead of print] 34. Shefer G, Marcus Y, Knoll E, Dolkart O, Foichtwanger S, Nevo N, Limor, R, Stern N: Angiotensin1-7 is a negative modulator of aldosterone in vitro and in vivo. Hypertension 2016; 68:378-84 35. Greenman Y , Cooper O, Yaish I, Robenshtok E , Sagiv N, Jonash KT, Yuan X, Gertych A, Shimon I, Ram Z, Melmed S,, Stern N: Treatment of clinically non-functioning pituitary adenomas with dopamine agonists. Europ. J Endocrinol. 2016; 175:63-72 36. Ganz T, Weinstein J, Gilad, S, Limor R, Boaz M, Stern N: Hypoargininemia predicts microvascular complications in type 2 diabetes mellitus. Diabetes and Metab. Res. Rev, 2016, in press. 37. Eyal O, Limor R, Oren A, Schachter-Davidov A, Stern N, Weintrob N. Establishing Normal Ranges of Basal and ACTH-Stimulated Serum Free Cortisol in Children. Horm Res Paediatr. 2016 Jul 20. [Epub ahead of print] 38. Sofer Y, Osher E, Limor R, Shefer G, Marcus Y, Shapira I, Tordjman K, Greenman Y, Berliner S, Stern N. Gender determines serum free cortisol : higher levels in men. Endocrine Pract. ;22:1415-1421, 2016 39. Marso SP, Bain SC, Consoli A, Eliaschewitz FG, Jódar E, Leiter LA, Lingvay I, Rosenstock J, Seufert J, Warren ML, Woo V, Hansen O, Holst AG, Pettersson J, Vilsbøll T; SUSTAIN-6 Investigators. Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes. N Engl J Med. 375:1834-1844, 2016 40. Greenman Y, Stern N: Paradoxical and atypical responses to pasireotide in aggressive ACTH-secreting pituitary tumors. Pituitary. 19:605-611, 2016 41. Tordjman K, Grinshpan L, Novack L, Göen T, Segev D, Beacher L, Stern N, Berman T. Exposure to endocrine disrupting chemicals among residents of a rural vegetarian/vegan community. Tordjman K, Grinshpan L, Novack L, Göen T, Segev D, Beacher L, Stern N, Berman T. Environ Int. 97:68-75, 2016 42. Somjen D, Sharfman ZT, Katzburg S, Sharon O, Maman E, Salai M, Stern N, Dolkart O. Rivaroxaban significantly inhibits the stimulatory effects of bone-modulating hormones: In vitro study of primary female osteoblasts. Connect Tissue Res. 58:215-220, 2017 43. le Roux CW, Astrup A, Fujioka K, Greenway F, Lau DCW, Van Gaal L, Ortiz RV, Wilding JPH, Skjøth TV, Manning LS, Pi-Sunyer X; SCALE Obesity Prediabetes NN8022-1839 Study Group. 3 years of liraglutide versus placebo for type 2 diabetes risk reduction and weight management in individuals with prediabetes: a randomised, double-blind trial. Lancet. 8;389:1399-1409, 2017 44. Holman RR, Bethel MA, Mentz RJ, Thompson VP, Lokhnygina Y, Buse JB, Chan JC, Choi J, Gustavson SM, Iqbal N, Maggioni AP, Marso SP, Öhman P, Pagidipati NJ, Poulter N, Ramachandran A, Zinman B, Hernandez AF; EXSCEL Study Group. Effects of Once-Weekly Exenatide on Cardiovascular Outcomes in Type 2 Diabetes. N Engl J Med. 28;377:1228-1239, 2017 45. Somjen D, Knoll E, Sharon O, Many A, Stern N.: Interaction between the effects of the selective estrogen modulator femarelle and a vitamin D analog in human umbilical artery vascular smooth muscle cells. J Steroid Biochem Mol Biol. 2017 May 20. pii: S0960-0760(17)30131-0. doi: 10.1016/j.jsbmb.2017.05.007. [Epub ahead of print] 46. Marcus Y, Osher E, Stern N. In the Treatment of Hypertension, Lowering of Diastolic Pressure to <70 mm Hg Is Often Unavoidable. J Am Coll Cardiol. 28;69:1647-1648. 2017 47. Buch A, Kis O, Carmeli E, Keinan-Boker L, Berner Y, Barer Y, Shefer G, Marcus Y, Stern N. Circuit resistance training is an effective means to enhance muscle strength in older and middle aged adults: A systematic review and meta-analysis. Ageing Res Rev. 37:16-27, 2017 48. Izkhakov E, Barchana M, Liphshitz I, Silverman BG, Stern N, Keinan-Boker L. Trends of Second Primary Malignancy in Patients with Thyroid Cancer: A Population-Based Cohort Study in Israel. Thyroid. 27:793-801. 2017 49. Azzam I, Gilad S, Limor R, Stern N, Greenman Y.: Ghrelin stimulation by hypothalamo-pituitary-adrenal axis activation depends on increasing cortisol levels. Endocr Connect. 6:847-855 2017. 50. Sofer Y, Nevo N, Vechoropoulos M, Shefer G, Osher E, Landis N, Tordjman K, Hammond GL, Stern N: Human sex hormone-binding globulin does not provide metabolic protection against diet-induced obesity and dysglycemia in mice. Endocr Connect.7:91-96; 2018 51. Milwidsky A, Fisher E, Brzezinski RY, Ehrenwald M, Shefer G, Stern N, Shapira I, Zeltser D, Rosenbaum Z, Greidinger D, Berliner S, Shenhar-Tsarfaty S, Rogowski O.: Metabolic syndrome is associated to high-sensitivity cardiac troponin T elevation. Biomarkers. 2018 Oct 25:1-6. doi: 10.1080/1354750X.2018.1528630. [Epub ahead of prin] 52. Buch A, Keinan-Boker L, Kis O, Carmeli E, Izkhakov E, Ish-Shalom M, Berner Y, Shefer G, Marcus Y, Stern N.: Severe central obesity or diabetes can replace weight loss in the detection of frailty in obese younger elderly - a preliminary study. Clin Interv Aging. 2018; 8;13:1907-1918. 53. Shahal T, Koren O, Shefer G, Stern N, Ebenstein Y. Hypersensitive quantification of global 5-hydroxymethylcytosine by chemoenzymatic tagging. Anal Chim Acta. 2018; 1038:87-96. 54. Rouach V, Goldshtein I, Wolf I, Catane R, Chodick G, Iton A, Stern N, Cohen D.: Exposure to alendronate is associated with a lower risk of bone metastases in osteoporotic women with early breast cancer. J Bone Oncol. 2018;12:91-95. 55. Buch A, Carmeli E, Shefer G, Keinan-Boker L, Berner Y, Marcus Y, Goldsmith R, Stern N.: Cognitive impairment and the association between frailty and functional deficits are linked to abdominal obesity in the elderly. Maturitas. 2018; 114:46-53. 56. Shaklai S, Grafi-Cohen M, Sharon O, Sagiv N, Shefer G, Somjen D, Stern N.: Pancreatic Beta-Cell Proliferation Induced by Estradiol-17β is Foxo1 Dependent. Horm Metab Res. 2018 ;50:485-490. 57. Izkhakov E, Sharon O, Knoll E, Aizic A, Fliss DM, Kohen F, Stern N, Somjen D.: A sorafenib-sparing effect in the treatment of thyroid carcinoma cells attained by co-treatment with a novel isoflavone derivative and 1,25 dihydroxyvitamin D3. J Steroid Biochem Mol Biol. 2018; 182:81-86. 58. Buch A, Keinan-Boker L, Berner Y, Carmeli E, Goldsmith R, Stern N.: Estimated frailty prevalence among Israeli elderly - results from a cross sectional national survey. Isr J Health Policy Res. 2018 12;7(1):18. doi: 10.1186/s13584-018-0212-5. 59. Brzezinski RY, Fisher E, Ehrenwald M, Shefer G, Stern N, Shapira I, Zeltser D, Berliner S, Shenhar-Tsarfaty S, Milwidsky A, Rogowski O.: Elevated high-sensitive troponin T in negative stress test individuals. Eur J Clin Invest. 2018 ;48:e12930. doi: 10.1111/eci.12930. 60. Yaish I, Azem F, Gutfeld O, Silman Z, Serebro M, Sharon O, Shefer G, Limor R, Stern N, Tordjman KM.: A Single Radioactive Iodine Treatment Has a Deleterious Effect on Ovarian Reserve in Women with Thyroid Cancer: Results of a Prospective Pilot Study. Thyroid. 2018; 28:522-52 61. Fisher E, Brzezinski RY, Ehrenwald M, Shapira, Zeltser D, Berliner S, Marcus Y, Shefer G, Stern N, Rogowski O, Halperin E, Rosset S, Shenhar-Tsarfaty S: Increase of body mass index and waist circumference predicts development of metabolic syndrome criteria in apparently healthy individuals with 2 and 5 years follow-up. Int J Obes (Lond). 2019 62. Izkhakov E, Meyerovitch J, Barchana M, Shacham Y, Stern N, Keinan-Boker L. Long-term cardiovascular and cerebrovascular morbidity in Israeli thyroid cancer survivors. Endocr Connect. 2019, Mar 1. pii: EC-19-0038.R1. doi: 10.1530/EC-19-0038. [Epub ahead of print]. 63. Rosenblum RC, Shtabsky A, Marmor S, Trejo L, Yaish I, Barnes S, Yehuda M, Stern N, Silman Z, Tordjman KM: Indeterminate nodules by the Bethesda system for reporting thyroid cytopathology in Israel: Frequency, and risk of malignancy after reclassification of follicular thyroid neoplasm with papillary-like features. Eur J Surg Oncol. 2019 Mar 15. pii: S0748-7983(19)30340-3. doi: 10.1016/j.ejso.2019.03.015. [Epub ahead of print]. 64. Zimmet P, Alberti KGMM, Stern N, Bilu C, El-Osta A, Einat H, Kronfeld-Schor N. The Circadian Syndrome: is the metabolic syndrome and much more! J Intern Med. 2019; 286(2):181-191. doi: 10.1111/joim.12924. 65. Izkhakov E, Vaisman N, Barnes S, Barchana M, Stern N, Keinan-Boker L: Body composition, resting energy expenditure and metabolic changes in women diagnosed with differentiated thyroid carcinoma. Thyroid. 29):1044-1051, 2019. doi: 10.1089/thy.2018.0483. 66. Tal B, Sack J, Yaron M, Shefer G, Buch A, Ben Haim L, Marcus Y, Shenkerman G, Sofer Y, Shefer L, Margaliot M, Stern N.: Increment in Dietary Potassium Predicts Weight Loss in the Treatment of the Metabolic Syndrome. Nutrients. 2019 Jun 2;11(6). pii: E1256. doi: 10.3390/nu11061256 67. Kis O, Buch A, Stern N, Moran DS: Minimally supervised home-based resistance training and muscle function in older adults: A meta-analysis. Arch Gerontol Geriatr. 2019 Sep - Oct;84:103909. doi: 10.1016/j.archger.2019.103909. 68. Rouach V, Goldshtein I, Buch A, Catane R, Chodick G, Stern N, Shalev V, Cohen D. The association between adherence with oral bisphosphonates and the risk of breast cancer in post-menopausal women. J Bone Oncol. 2018 Nov 6;16:100202. doi: 10.1016/j.jbo.2018.10.001. 69. Buch A, Eldor R, Kis O, Keinan-Boker L, Dunsky A, Rubin A, Lopez A7, Sofer Y, Osher E, Marcus Y, Stern N.The effect of circuit resistance training, empagliflozin or "vegeterranean diet" on physical and metabolic function in older subjects with type 2 diabetes: a study protocol for a randomized control trial (CEV-65 trial). BMC Geriatr. 2019. Aug 22;19(1):228. doi: 10.1186/s12877-019-1219-7 70. Shaklai S, Grafi-Cohen M, Sharon O, Shefer G, Somjen D, Stern N: Estradiol 17-β Induces Pancreatic Beta-Cell Proliferation through Distinct Estrogen Receptors in a Glucose Dependent Manner. OBM Transplantation 2019;3(3):11; doi:10.21926/obm.transplant.1903082. 71. Husain M, Birkenfeld AL, Donsmark M, Dungan K, Eliaschewitz FG, Franco DR, Jeppesen OK, Lingvay I, Mosenzon O, Pedersen SD, Tack CJ, Thomsen M, Vilsbøll T, Warren ML, Bain SC; PIONEER 6 Investigators. Oral Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes. N Engl J Med. 2019 ;381:841-851. 72. Markus E, Trestman S, Cohen Y, Angel Y, Sofer Y, Mittelman M, Avivi I, Stern N, Izkhakov E.: Components of metabolic syndrome in patients with multiple myeloma and smoldering multiple myeloma. BMC Cancer. 2020 ;20(1):489. doi: 10.1186/s12885-020-06976-1 73. Marcus Y, Eldor R, Yaron M, Shaklai S, Ish-Shalom M, Shefer G, Stern N, Golan N, Dvir AZ, Pele O, Gonen M. Improving blood glucose level predictability using machine learning. Diabetes Metab Res Rev. 2020 May 23:e3348. doi: 10.1002/dmrr.3348 74. Ofir O, Buch A, Rouach V, Goldsmith R, Stern N, Monsonego-Ornan E: Association between abdominal obesity and fragility fractures among elderly Israeli women.Aging Clin Exp Res. 2019 Sep 14. doi: 10.1007/s40520-019-01347-8. 75. Sofer Y, Yaish I, Yaron M, Bach MY, Stern N, Greenman Y.: Differential Endocrine and Metabolic Effects of Testosterone Suppressive Agents in Transgender Women. Endocr Pract. 2020; 26:883-890. doi: 10.4158/EP-2020-0032. 76. Izkhakov E, Keinan-Boker L, Barchana M, Shacham Y, Yaish I, Carmel Neiderman NN, Fliss DM, Stern N, Meyerovitch J.; Long-term all-cause mortality and its association with cardiovascular risk factors in thyroid cancer survivors: an Israeli population-based study. BMC Cancer. 2020 Sep 17;20(1):892. doi: 10.1186/s12885-020-07401-3. PMID: 32942995 77. Buch A, Magid A, Eldor R, Keinan-Boker L, Ben Haim L, Greenman Y, Stern N. Nutritional profiling of frail and obese, community dwelling older subjects: Results from a national survey. Exp Gerontol. 2020 Dec;142:111112. doi: 10.1016/j.exger.2020.111112. Epub 2020 Oct 13. PMID: 33065229 78. Izkhakov E, Zahler D, Rozenfeld KL, Ravid D, Banai S, Topilsky Y, Stern N, Greenman Y, Shacham Y.: Unknown Subclinical Hypothyroidism and In-Hospital Outcomes and Short- and Long-Term All-Cause Mortality among ST Segment Elevation Myocardial Infarction Patients Undergoing Percutaneous Coronary Intervention. J Clin Med. 2020 Nov 26;9(12):3829. doi: 10.3390/jcm9123829. PMID: 33256094 79. Horowitz G, Ish-Shalom M, Warshavsky A, Stern N, Fliss DM, Comaneshter D, Vinker S.: Thyroid function control among pregnant women following a therapeutic thyroidectomy. Clin Otolaryngol. 2020 Dec 8. doi: 10.1111/coa.13687. Online ahead of print. PMID: 33290623 80. Shi Z, Tuomilehto J, Kronfeld-Schor N, Alberti GK, Stern N, El-Osta A, Bilu C, Einat H, Zimmet P: J Intern Med. 2020 Dec 19. doi: 10.1111/joim.13204. Online ahead of print. PMID: 33340184 81. Sofer Y, Nash Y, Osher E, Fursht O, Goldsmith G, Nahary L, Shaklai S, Tordjman KM, Serebro M, Touati EB, Yacobi Bach M, Marcus Y, Tal B, Sack J, Shefer G, Margaliot M, Landis N, 82. Goldiner I, Abu Ahmad W, Stern N, Benhar I, Frenkel D.: Insulin-degrading enzyme higher in subjects with metabolic syndrome. Endocrine. 2021 Jan 4. doi: 10.1007/s12020-020-02548-2. 83. Shapira S, Kazanov D, Dankner R, Fishman S, Stern N, Arber N.: High Expression Level of PPARγ in CD24 Knockout Mice and Gender-Specific Metabolic Changes: Model of Insulin-Sensitive Obesity. J Pers Med. 2021 ;11(1): E50. doi: 10.3390/jpm11010050. 84. Sofer Y, Yaish I, Yaron M, Bach MY, Stern N, Greenman Y. Differential Endocrine and Metabolic Effects of Testosterone Suppressive Agents in Transgender Women. Endocr Pract. 2020 Aug;26(8):883-890. doi: 10.4158/EP-2020-0032. PMID: 33471679 85. Buch A, Diener J, Stern N, Rubin A, Kis O, Sofer Y, Yaron M, Greenman Y, Eldor R, Eilat-Adar S. Comparison of Equations Estimating Resting Metabolic Rate in Older Adults with Type 2 Diabetes. J Clin Med. 2021 Apr 12;10(8):1644. doi: 10.3390/jcm10081644. 86. Rosset A, Greenman Y, Osher E, Stern N, Tordjman K. Revisiting Cushing's Syndrome, Milder Forms Are Now a Common Occurrence- A Single Center Cohort of 76 Subjects. Endocr Pract. 2021 Feb 27:S1530-891X(21)00056-2. doi: 10.1016/j.eprac.2021.02.012. 87. Shaklai S, Yom-Tov E, Gilad Bachrach R, Stern N: Risk of impending stroke can be detected through cognitive traits evident in internet searches: Analysis of archival data and proposed perspective. J Internet Med Res, in press, 2021. 88. Izkhakov E, Lital Keinan-Boker L, Stern N: Cardiovascular Morbidity and Mortality as a Confounder of Prognosis in Thyroid Cancer. J Cancer Metastases Treatment, in press, 2021